Other severe systemic autoimmune conditions, including connective tissue diseases
Adequate organ function:
Cardiac LV Ejection Fraction >45%
Total Lung capacity > 60%
Pulmonary artery pressure < 45 mmHg.
Any condition that affects normal functions of organs such as heart, kidneys, lung, liver etc.
As this would limit your ability to receive high-dose chemotherapy immunosuppressive therapy with AHSCT.
Any active or long term infection caused by viruses, fungi or bacteria.
A positive test for HIV, Hepatitis B and Hepatitis C.
Life expectancy is severely limited by another illness.
Evidence myelodysplasia or other non-autoimmune cytopenia.
Having received a cytotoxic agent within one month prior to AHSCT.
Pregnancy or at risk of pregnancy, including those unwilling to practice active contraception during the time of therapy.
Psychiatric illness, mental deficiency, or gross cognitive dysfunction.
Unability to give written informed consent in accordance with research ethics board guidelines.
High disability level in MS patients (EDSS>6.5) and/or stable non-active disease during the last 2 years
Please, try to be objective... Despite the results of the questionnaire review, the final decision of approvement for treatment will be based on the results of a pre - transplant examination in Moscow.
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